Wednesday, 14th May 51st International Society for the Study of the Lumbar Spine Annual Meeting 2025

• Impact of obesity and type 2 diabetes on intervertebral disc degeneration progression in a mouse tail-loop model - Clara Ruiz-Fernandez
• Tie2-enhanced nucleus pulposus cell-derived extracellular vesicles increase degenerative disc cell proliferation, ameliorate senescence, and present distinct proteomic signatures compared to mesenchymal stromal cell-derived extracellular vesicles - Luca Ambrosio
• Evaluating hyaluronic acid and alginate as biomaterial carriers for nucleus pulposus cell transplantation in a canine disc degeneration model - Jordy Schol
• The impact of overall lumbar disc degeneration burden on disability outcomes following surgery for lumbar spinal stenosis due to osteoarthritis - Y. Raja Rampersaud
• A novel conditional genetic mouse model of accelerated intervertebral disc degeneration provides insights into chronic low back pain  - Ravij Mehta
• Impacting flexed ovine lumbar motion segments increases the risk of endplate fracture with subtle structural damage: is it a potential initiator of subsequent disc degeneration? - Vonne M van Heeswijk

• In-field assessment of pain and physical activities of individuals with chronic low back pain using ecological momentary assessment and wearable sensors - Kevin M Bell
• Do the Lower Extremities influence the Cone of Economy of Patients with Radiculopathy and Neurogenic Claudication? An Innovative Approach - Ram Haddas
• Phenotyping of Chronic Low Back Pain Using Wearable Sensor-Enabled Functional Motion Assessments - William S Marras
• Targeting coordination: how focus of attention influences spinal movement control in low back pain - Cathrine H. Feier
• Does bone marrow edema on early postoperative MRI predict unsuccessful healing of interbody fusion? - Yukitoshi Shimamura
• Chronic Alcohol Consumption Induces Intervertebral Disc Degeneration by Enhancing Inflammation and Matrix Degradation - Svenja Illien-Junger

• Comparative Analysis of ALIF and TLIF: Assessing Lumbar Lordosis Restoration and Adjacent Segment Disease Risk in Degenerative Lumbar Conditions - Xudong Li
• Impact of Restricted Prophylactic Antibiotic Guidelines on Surgical Site Infections in Elective Spinal Surgeries: A Nationwide Study in South Korea - Jun-Seok Lee
• Cost-utility analysis of a pre-, peri- and postoperative rehabilitation pathway versus usual care in patients undergoing lumbar fusion surgery - Liedewij Bogaert
• The validity, reliability, and responsiveness of questionnaires and objective measures before and after surgery for lumbar spinal stenosis. - David Anderson
• Evaluating the Combined Effects of Posterior Column Osteotomy and Transforaminal Lumbar Interbody Fusion on Surgical Outcomes: A Comprehensive Retrospective Study - Xudong Li
• Open vs. minimally invasive spine surgery in the treatment of single-level grade I degenerative lumbar spondylolisthesis: an AO Spine global cross-sectional study - Luca Ambrosio

• Trident Approach to Chronic Low Back Pain Classification: A Comprehensive Cohort Study of Patients with Nociceptive and Neuropathic Pain Assessed by the PainDETECT Questionnaire - Stone Sima
• Evaluation of postoperative outcomes in lumbar disc herniation with focus on preoperative Modic changes and their type alterations. - Masashi Sato
• Sex- and Age-Specific Prevalence of Lumbar Intervertebral Degeneration and Its Association with Chronic Back Pain: First Insights from a Large-Scale Spine MRI Analysis on the German National Cohort - Matan Atad
• Exercise Treatment for Chronic Low Back Pain: A Longitudinal Analysis of Trajectory Patterns and Psychosocial Factors - Aileen Chou
• The causal association between chronic back pain and accelerated cognitive decline in older adults: big data analysis from four databases - Arnold Wong
• Inflammatory phenotypes in non-specific chronic low back pain - Conor ONeill

Three oral presentations will be followed by a 15-minute panel discussion.

• 7 Years Follow-up in a Large Population-Based Cohort: Relationship Between Changes in Low Back Pain and Spinal Phenotypes in the Wakayama Spine Study - Kimihide Murakami
• AI-Driven Phenotyping to Investigate Biopsychosocial Factors Affecting Return-to-Work in Chronic Low Back Pain Workers - Luca Ambrosio
• Bridging the gap: understanding and enhancing the collaborative relationship between spine clinicians and researchers of the International Society for the Study of the Lumbar Spine (ISSLS) - Fabio Galbusera
• Effect of pharmacological treatment on osteoporotic vertebral fractures in late-stage elderly patients (J-BOLD study extension): retrospective cohort study using large-scale claim database - Toshio Nakamae
• Does occult infection account for disc degeneration with type 1 Modic change in the lumbar spine? - Frances MK Williams

Three oral presentations will be followed by a 15-minute panel discussion.

• A Functional Analysis of Symmetric Lifting Movements in Patients with Lumbar Stenosis - Kade Kaufmann
• Development and Validation of a Machine Learning Model for Classifying Postoperative Physical Activity Patterns Using Wearable Accelerometer Data in Patients with Lumbar Degenerative Disease - Tatsuya Endo
• Comparison of O-arm Based Navigation System and Conventional Fluoroscopy in Percutaneous Screw Fixation for Fragility Fractures of the Pelvis - Masaya Mizutani
• Radiological vertebral fracture with spinal sagittal imbalance associated with future long-term care needs in the local community residents. - Kazuyuki Watanabe
• Short fixation using upward/downward endplate penetrating screws and percutaneous vertebral augmentation for unstable osteoporotic vertebral fractures - Kengo Fujii

Stroll through the renowned Georgia Aquarium then join thousands of locals as they cheer on the Atlanta Braves baseball team at their home game. Enjoy a dedicated space with traditional catering.